Jun 19, 2013

By Kathryn Doyle

NEW YORK (Reuters Health) Jun 19 - Women may expect hot flashes as a part of the "change of life," but more than half start sweating before menopause has actually begun, according to a survey.

The study and others "indicate that women start having hot flashes and night sweats, the primary symptoms of the menopause transition, before they have their final menstrual period, contrary to the perception of many clinicians," according to Dr. Ellen Gold, of the University of California, Davis School of Medicine.

Previous studies put the number of women with hot flashes at 15% or 20%, but those specifically asked about hot flashes in the past two weeks, which may be a better measure of early onset menopause symptoms than the current study, which asked "have you ever had a hot flash," said Dr. Gold, who was not involved in the study.

The findings, published online June 10 in Menopause, shouldn't be a concern for women, but it may change how researchers look at hot flashes, according to lead author Dr. Susan Reed who studies women's mid-life health at the University of Washington in Seattle.

She and her coauthors sent questionnaires to 18,500 women between 45 and 56. About half responded. Of the 1,500 who still had regular cycles and weren't taking medications such as antibiotics or hormone replacement, 55% reported having experienced a hot flash or night sweat at some point in their lives.

More than half of white, black and Native American women reported the symptoms, compared to 30% or fewer of Asian and Hispanic women.

The study was funded by Otsuka Pharmaceutical Co., Ltd., which is developing S-Equol, a compound that may mimic estrogen and could be a potential treatment for menopausal symptoms.

Many women have hot flashes but don't find that they disrupt daily life, said Dr. Ellen Freeman, of the University of Pennsylvania Perelman School of Medicine in Philadelphia.

"Note that only 22% were 'bothered,'" so more than half of the women who had experienced a hot flash weren't troubled by it, Dr. Freeman told Reuters Health by email.

Though it wasn't their primary aim, the researchers also looked at how much soy the women reported eating. Soybeans contain weak estrogen-like compounds, which are not as strong as estrogen but have been linked to reduced fertility and early puberty in women.

Among white women, those with menopausal symptoms seemed more likely to eat soy regularly, while white women without symptoms were more likely to never have eaten soy. There was no relationship with soy in the other ethnic groups.

Though a study from last year found that eating soy doesn't alleviate hot flashes, it's also too early to say that soy causes hot flashes, Dr. Freeman said.

Given the design of the study, "it is possible that those women with hot flashes had increased soy intake to try to manage their hot flashes -- we don't know which came first," Dr. Reed's coauthor Katherine Newton told Reuters Health.

SOURCE: http://bit.ly/11goEec

Menopause 2013.

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